Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination
نویسندگان
چکیده
منابع مشابه
Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination.
LNX (Ligand of Numb Protein-X) proteins, LNX1 and LNX2, are RING- and PDZ-based E3-ubiquitin ligases known to interact with Numb. Silencing of LNX2 has been reported to down-regulate WNT and NOTCH, two key signaling pathways in tumorigenesis. Here we report the identification of the domain boundary of LNX2 to confer its ubiquitination activity, its crystal structure along with functional studie...
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Treble clef finger--a functionally diverse zinc-binding structural motif.
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5326